Advancing Nuclear Medicine Through Innovation - download pdf or read online

By National Research Council, Institute of Medicine, Board on Health Sciences Policy, Division on Earth and Life Studies, Nuclear and Radiation Studies Board, Committee on State of the Science of Nuclear Medicine

ISBN-10: 030911067X

ISBN-13: 9780309110679

ISBN-10: 0309110688

ISBN-13: 9780309110686

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In lymphoma) (Kelloff et al. 2005). 1 SIGNIFICANT DISCOVERIES The modern era of nuclear medicine is an outgrowth of the charge to the Atomic Energy Commission (AEC) “to exploit nuclear energy to promote human health” (Atoms for Peace Program). For more than 50 years, the AEC and later the Department of Energy (DOE) have supported high-risk research and development of nuclear medicine technology and have supplied radionuclides to the research community including physicists, chemists, engineers, computer scientists, biologists, and physicians.

These new detector materials will substantially improve nuclear medicine imaging when incorporated into next-generation PET and SPECT devices. Combined-Modality Imaging (PET/CT, PET/MRI, and SPECT/CT) CT, MRI, and PET all provide complementary “views” of normal and diseased tissues, with PET offering quantitative functional information and MRI and CT scans providing high-resolution anatomical information. The power of combined-modality imaging will increase dramatically as molecularly targeted radiotracers with high specific activity are developed and as the sensitivity and resolution of PET increase to allow for high-resolution, temporal imaging.

For clinical trials to be successful, industry must be engaged and see a clear pathway for economic success. Industry will not develop the technology necessary to deploy the next generation of genome-based medicines unless the scientific and economic rationale has been identified by academia. 14 In its March 2004 Critical Path Report, the FDA stated that new tools were needed to distinguish earlier in the drug development process which candidates hold promise and which ones do not. Because only 8 percent of new medical compounds entering phase I testing reach the market, the FDA established eIND studies as a way of trying to reduce the time and cost of drug development.

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Advancing Nuclear Medicine Through Innovation by National Research Council, Institute of Medicine, Board on Health Sciences Policy, Division on Earth and Life Studies, Nuclear and Radiation Studies Board, Committee on State of the Science of Nuclear Medicine

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